123 research outputs found
An IoT Endpoint System-on-Chip for Secure and Energy-Efficient Near-Sensor Analytics
Near-sensor data analytics is a promising direction for IoT endpoints, as it
minimizes energy spent on communication and reduces network load - but it also
poses security concerns, as valuable data is stored or sent over the network at
various stages of the analytics pipeline. Using encryption to protect sensitive
data at the boundary of the on-chip analytics engine is a way to address data
security issues. To cope with the combined workload of analytics and encryption
in a tight power envelope, we propose Fulmine, a System-on-Chip based on a
tightly-coupled multi-core cluster augmented with specialized blocks for
compute-intensive data processing and encryption functions, supporting software
programmability for regular computing tasks. The Fulmine SoC, fabricated in
65nm technology, consumes less than 20mW on average at 0.8V achieving an
efficiency of up to 70pJ/B in encryption, 50pJ/px in convolution, or up to
25MIPS/mW in software. As a strong argument for real-life flexible application
of our platform, we show experimental results for three secure analytics use
cases: secure autonomous aerial surveillance with a state-of-the-art deep CNN
consuming 3.16pJ per equivalent RISC op; local CNN-based face detection with
secured remote recognition in 5.74pJ/op; and seizure detection with encrypted
data collection from EEG within 12.7pJ/op.Comment: 15 pages, 12 figures, accepted for publication to the IEEE
Transactions on Circuits and Systems - I: Regular Paper
A -1.8V to 0.9V body bias, 60 GOPS/W 4-core cluster in low-power 28nm UTBB FD-SOI technology
A 4-core cluster fabricated in low power 28nm UTBB FD-SOI conventional well technology is presented. The SoC architecture enables the processors to operate 'on-demand' on a 0.44V (1.8MHz) to 1.2V (475MHz) supply voltage wide range and -1.2V to 0.9V body bias wide range achieving the peak energy efficiency of 60 GOPS/W, (419\u3bcW, 6.4MHz) at 0.5V with 0.5V forward body bias. The proposed SoC energy efficiency is 1.4x to 3.7x greater than other low-power processors with comparable performance
Approximate 32-Bit Floating-Point Unit Design with 53% Power-Area Product Reduction
The floating-point unit is one of the most common building block in any computing system and is used for a huge number of applications. By combining two state-of-the-art techniques of imprecise hardware, namely Gate-Level Pruning and Inexact Speculative Adder, and by introducing a novel Inexact Speculative Multiplier architecture, three different approximate FPUs and one reference IEEE-754 compliant FPU have been integrated in a 65 nm CMOS process within a low-power multi-core processor. Silicon measurements show up to 27% power, 36% area and 53%power-area product savings compared to the IEEE-754 single-precision FPU. Accuracy loss has been evaluated with a high-dynamic-range image tone-mapping algorithm, resulting in small but non-visible errors with image PSNR value of 90 dB
Sparse Pseudospectral Approximation Method
Multivariate global polynomial approximations - such as polynomial chaos or
stochastic collocation methods - are now in widespread use for sensitivity
analysis and uncertainty quantification. The pseudospectral variety of these
methods uses a numerical integration rule to approximate the Fourier-type
coefficients of a truncated expansion in orthogonal polynomials. For problems
in more than two or three dimensions, a sparse grid numerical integration rule
offers accuracy with a smaller node set compared to tensor product
approximation. However, when using a sparse rule to approximately integrate
these coefficients, one often finds unacceptable errors in the coefficients
associated with higher degree polynomials.
By reexamining Smolyak's algorithm and exploiting the connections between
interpolation and projection in tensor product spaces, we construct a sparse
pseudospectral approximation method that accurately reproduces the coefficients
of basis functions that naturally correspond to the sparse grid integration
rule. The compelling numerical results show that this is the proper way to use
sparse grid integration rules for pseudospectral approximation
Implementation of the Combined--Nonlinear Condensation Transformation
We discuss several applications of the recently proposed combined
nonlinear-condensation transformation (CNCT) for the evaluation of slowly
convergent, nonalternating series. These include certain statistical
distributions which are of importance in linguistics, statistical-mechanics
theory, and biophysics (statistical analysis of DNA sequences). We also discuss
applications of the transformation in experimental mathematics, and we briefly
expand on further applications in theoretical physics. Finally, we discuss a
related Mathematica program for the computation of Lerch's transcendent.Comment: 23 pages, 1 table, 1 figure (Comput. Phys. Commun., in press
Gaussian quadrature rules for C1 quintic splines with uniform knot vectors
We provide explicit quadrature rules for spaces of C1 quintic splines with uniform knot sequences over finite domains. The quadrature nodes and weights are derived via an explicit recursion that avoids numerical solvers. Each rule is optimal, that is, requires the minimal number of nodes, for a given function space. For each of n subintervals, generically, only two nodes are required which reduces the evaluation cost by 2/3 when compared to the classical Gaussian quadrature for polynomials over each knot span. Numerical experiments show fast convergence, as n grows, to the “two-third” quadrature rule of Hughes et al. (2010) for infinite domains
From Euler's play with infinite series to the anomalous magnetic moment
During a first St. Petersburg period Leonhard Euler, in his early twenties,
became interested in the Basel problem: summing the series of inverse squares
(posed by Pietro Mengoli in mid 17th century). In the words of Andre Weil
(1989) "as with most questions that ever attracted his attention, he never
abandoned it". Euler introduced on the way the alternating "phi-series", the
better converging companion of the zeta function, the first example of a
polylogarithm at a root of unity. He realized - empirically! - that odd zeta
values appear to be new (transcendental?) numbers. It is amazing to see how, a
quarter of a millennium later, the numbers Euler played with, "however
repugnant" this game might have seemed to his contemporary lovers of the
"higher kind of calculus", reappeared in the analytic calculation of the
anomalous magnetic moment of the electron, the most precisely calculated and
measured physical quantity. Mathematicians, inspired by ideas of Grothendieck,
are reviving the dream of Galois of uncovering a group structure in the ring of
periods (that includes the multiple zeta values) - applied to the study of
Feynman amplitudes.Comment: v.2: minor corrections, references adde
Efficacy and safety of D,L-3-hydroxybutyrate (D,L-3-HB) treatment in multiple acyl-CoA dehydrogenase deficiency
PURPOSE: Multiple acyl-CoA dehydrogenase deficiency (MADD) is a life-threatening, ultrarare inborn error of metabolism. Case reports described successful D,L-3-hydroxybutyrate (D,L-3-HB) treatment in severely affected MADD patients, but systematic data on efficacy and safety is lacking.METHODS: A systematic literature review and an international, retrospective cohort study on clinical presentation, D,L-3-HB treatment method, and outcome in MADD(-like) patients.RESULTS: Our study summarizes 23 MADD(-like) patients, including 14 new cases. Median age at clinical onset was two months (interquartile range [IQR]: 8 months). Median age at starting D,L-3-HB was seven months (IQR: 4.5 years). D,L-3-HB doses ranged between 100 and 2600 mg/kg/day. Clinical improvement was reported in 16 patients (70%) for cardiomyopathy, leukodystrophy, liver symptoms, muscle symptoms, and/or respiratory failure. D,L-3-HB appeared not effective for neuropathy. Survival appeared longer upon D,L-3-HB compared with historical controls. Median time until first clinical improvement was one month, and ranged up to six months. Reported side effects included abdominal pain, constipation, dehydration, diarrhea, and vomiting/nausea. Median D,L-3-HB treatment duration was two years (IQR: 6 years). D,L-3-HB treatment was discontinued in 12 patients (52%).CONCLUSION: The strength of the current study is the international pooling of data demonstrating that D,L-3-HB treatment can be effective and safe in MADD(-like) patients.</p
Proteomic Changes Resulting from Gene Copy Number Variations in Cancer Cells
Along the transformation process, cells accumulate DNA aberrations, including mutations, translocations, amplifications, and deletions. Despite numerous studies, the overall effects of amplifications and deletions on the end point of gene expression—the level of proteins—is generally unknown. Here we use large-scale and high-resolution proteomics combined with gene copy number analysis to investigate in a global manner to what extent these genomic changes have a proteomic output and therefore the ability to affect cellular transformation. We accurately measure expression levels of 6,735 proteins and directly compare them to the gene copy number. We find that the average effect of these alterations on the protein expression is only a few percent. Nevertheless, by using a novel algorithm, we find the combined impact that many of these regional chromosomal aberrations have at the protein level. We show that proteins encoded by amplified oncogenes are often overexpressed, while adjacent amplified genes, which presumably do not promote growth and survival, are attenuated. Furthermore, regulation of biological processes and molecular complexes is independent of general copy number changes. By connecting the primary genome alteration to their proteomic consequences, this approach helps to interpret the data from large-scale cancer genomics efforts
Pan-RAF and MEK vertical inhibition enhances therapeutic response in non-V600 BRAF mutant cells
BACKGROUND: Currently, there are no available targeted therapy options for non-V600 BRAF mutated tumors. The aim of this study was to investigate the effects of RAF and MEK concurrent inhibition on tumor growth, migration, signaling and apoptosis induction in preclinical models of non-V600 BRAF mutant tumor cell lines. METHODS: Six BRAF mutated human tumor cell lines CRL5885 (G466 V), WM3629 (D594G), WM3670 (G469E), MDAMB231 (G464 V), CRL5922 (L597 V) and A375 (V600E as control) were investigated. Pan-RAF inhibitor (sorafenib or AZ628) and MEK inhibitor (selumetinib) or their combination were used in in vitro viability, video microscopy, immunoblot, cell cycle and TUNEL assays. The in vivo effects of the drugs were assessed in an orthotopic NSG mouse breast cancer model. RESULTS: All cell lines showed a significant growth inhibition with synergism in the sorafenib/AZ628 and selumetinib combination. Combination treatment resulted in higher Erk1/2 inhibition and in increased induction of apoptosis when compared to single agent treatments. However, single selumetinib treatment could cause adverse therapeutic effects, like increased cell migration in certain cells, selumetinib and sorafenib combination treatment lowered migratory capacity in all the cell lines. Importantly, combination resulted in significantly increased tumor growth inhibition in orthotropic xenografts of MDAMB231 cells when compared to sorafenib - but not to selumetinib - treatment. CONCLUSIONS: Our data suggests that combined blocking of RAF and MEK may achieve increased therapeutic response in non-V600 BRAF mutant tumors
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